姚宏

领域:生物与新医药

职称级别:教授,高级

    近年来,在抗肿瘤药物的高通量筛选、中药质量控制及体内过程研究、药品的质量控制等方面开展了大量研究工作。2014年入选福建省高等学校新世纪优秀人才支持计划,2015年入选福建省卫生系统中青年骨干人才。主持国家自然科学基金项目2项和省(部)级科研课题十余项。先后主持国家自然科学基金青年项目、面上项目各1项和省(部)级科研课题多项。近年来在Sensor Actuat B-Chem、Int J Nanomed、Drug Metab Rev、J Mol Med、Phytomed、Food Chem等SCI期刊上发表学术论文近60篇,获国家授权专利6项。2015年获福建省医学科技奖三等奖(1/5),2012年获陕西省科学技术一等奖(6/10),2011年获陕西高等学校科学技术奖一等奖(6/10),2010年获“陈可冀中西医结合发展基金”资助项目首届优秀论文二等奖,2007及2009年获福建省自然科学优秀学术论文三等奖等奖项。

    近一年发表研究论文举要:

    1. Peiying Shi; ...;  Yao, Hong (通讯作者). Non-covalent modification of glassy carbon electrode with isoorientin and application to alpha-fetoprotein detection by fabricating an immunosensor. Sensors & Actuators: B. Chemical, 2020, 305, 127494.

    2. Yao, Wensong; ...; Yao, Hong (通讯作者之一); et al. Delicaflavone induces ROS-mediated apoptosis and inhibits PI3K/AKT/ mTOR and Ras/MEK/Erk signaling pathways in colorectal cancer cells. Biochemical Pharmacology, 2020, 171, 113680.

    3. Chen, Bing; ...; Yao, Hong (通讯作者之一); et al. Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion. Drug Delivery, 2020, 27, 309-322.

    4. Yao, Wensong; ...; Yao, Hong (通讯作者之一); et al. Delicaflavone induces apoptosis via mitochondrial pathway accompanying G2/M cycle arrest and inhibition of MAPK signaling cascades in cervical cancer HeLa cells. Phytomedicine, 2019, 62, 152973.

    5. Chen, Bing; ...; Yao, Hong (通讯作者之一); et al. Proliposomes for oral delivery of total biflavonoids extract from Selaginella doederleinii: formulation development, optimization, and in vitro–in vivo characterization. International Journal of Nanomedicine, 2019, 14, 6691-6706.

    6. Li, Shaoguang; ...; Yao, Hong (通讯作者之一); et al. Protective effects of five compounds from Livistona chinensis R. Brown leaves against hypoxia/ reoxygenation, H2O2, or adriamycin-induced injury in H9c2 cells. Drug Design, Development and Therapy, 2019, 13, 1555-1566.

    7. Huang, Xuliang ; ... ; Yao, Hong (通讯作者之一); et al. Simultaneous Determination of Five Irdoid Glycosides and Three Flavonoid Glycosides in Hedyotis Diffusa Wild by UPLC-UV with Ultrasound-Assisted Extraction. Current Pharmaceutical Analysis, 2019, 15, 808-818.

    8.Xie, Yuanjiao; ... ; Yao, Hong (通讯作者之一); et al. Qualitative and Quantitative Analysis of the Major Ingredients of a Herbal Preparation, Ciwujia Injection by Combination of HPLC-Q-TOF-MS, HPLC-TQ-MS/MS and UPLC-PDA. Current Pharmaceutical Analysis, 2019, 15, 388-398.

    9. Huang, Jianyong; ... ; Yao, Hong (通讯作者之一); et al. An integrated pharmacokinetic study of Dengzhanxixin injection in rats by combination of multicomponent pharmacokinetics and antimyocardial ischemic assay. RSC Adv., 2019, 9, 25309.

    10. Peiying Shi; ...;  Yao, Hong (通讯作者). Simultaneous Determination of Five Phenolic Acids and Four Flavonoid Glycosides in Rat Plasma Using HPLC-MS/MS and Its Application to a Pharmacokinetic Study after a Single Intravenous Administration of Kudiezi Injection. Molecules, 2019, 24, 64

    基金项目举要:

    1. 国家自然科学基金面上项目:基于“分而治之”融合“效应加权”策略的冠心丹参方多成分整合药动学新方法研究,55万,81973558,2020/01-2023/12。(在研,主持人)

    2. 福建省科技创新联合资金项目:天然抗癌活性小分子Delicaflavone的抗肺癌作用机制、靶标及代谢特征研究,40万元,2017Y9123,2017.12-2020.12。(在研,主持人)

    3. 国家自然科学基金青年基金项目:冠心丹参方药代动力学标志性成分的择取研究,23万,81202987,2013/01-2015/12。(结题,主持人)

    4. 福建省自然科学基金面上项目:三种民间抗癌中草药的药效物质高效筛选及便于其质控的二维码建立研究,4万元,2016J01371,2016.04-2019.03。(结题,主持人)

    学术兼职:

    福建省药学会第七届中药和天然产物专业委员会委员


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